Download e-book for kindle: A Guide to Zona Pellucida Domain Proteins by Eveline S. Litscher, Paul M. Wassarman

By Eveline S. Litscher, Paul M. Wassarman

This e-book presents a coherent, transparent, and uniform presentation of structural, genetic, molecular, and biochemical info on hand for the zona pellucida area protein kinfolk, which effect pathologies equivalent to infertility, deafness, and melanoma. moreover it:

  • Details information regarding the constitution and serve as of the ZP area in ZPDC-proteins
  • Provides illustrations of the association of ZPDC-proteins, the genes that encode the proteins, and examples of mutations within the ZP area that reason diseases
  • Speculates as to the evolution of the ZP area and capability therapeutics for illnesses stemming from ZP area mutations
  • Addresses mammalian and non-mammalian systems

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Additional resources for A Guide to Zona Pellucida Domain Proteins

Example text

All three nascent ZP proteins have a TMD downstream of the CFCS. 2 Schematic representation of various features of mZP3. Shown are the positions of the SS (aa 1–22), ZPD (aa 45–302), IHP (aa 170–177), CFCS (aa 350–353), EHP (aa 357–369), TMD (aa 387–409), and CT (aa 410–424). The aa sequence of the CTP of mZP3, from aa 350–424, is shown together with the positions of the CFCS, EHP, TMD, and CT. Note that the IHP is located in the ZP‐N sub‐domain of the ZPD and that the EHP is located between the CFCS and TMD.

1 mqwillftlf sfiwgslget edldhpgtls cglrsfrfml pllsqygknp gliawdnkgm 61 lhslhndsic gtwityssle siqleasysg cyvtewdtyy impigvsgld adgsktvhkv 121 tvlncsftlp aqdapglnlC dvttedrlsC avpsitkgdC enlgCCyhpe devnpCyygn 181 tvtaqCtpdg qlsiavsqnm tqpsllldsi hlvsgldvkC dpvektnafv lfqfplssCg 241 tivqmidnqa iyknellasr dvrnwthgsi trdsifrlhi sCsyslkgdi lpasiqvftl 301 ppplpvtkpg plalelqiak eehyrsyyva tdypvtkllr epihvevril qrtdpnlvll 361 lhhCwatpnt nplhpirwpi lvkgCpyegd nyltkmvpmp rnstlqfpsh ykrfiihtfa 421 fvdsafkkal mgpvylhCsa svCqpsesds CtvtCpvgtr krrssethpw nkssnvssqg 481 pifflqvaes ypqsgpvldv rtlwltlsgi livavllvsf lalrrvk Further Reading Haines BP, Rathjen PD, Hope RM, Whyatt LM et al.

Biol Reprod 52, 1167–78 (1995). Stetson I, Izquierdo‐Rico MJ, Moros C, Chevret P et al. Rabbit zona pellucida composition: a molecular, proteomic and phylogenetic approach. J Proteomics 75, 5920–5935 (2012). e Cow The cow (Bos taurus) ZP consists of three proteins, called ZP2–4. zp1, 2, 3, and 4 have been characterized by cDNA cloning and zp1 was determined to be a pseudogene located on chromosome 29. 1). ZP2: The polypeptide of ZP2 consists of 713 aa residues and has an SS (aa 1–35; highlighted), a ZPD (aa 366–630; highlighted) with 10 Cys residues (aa 367, 398, 419, 460, 540, 561, 610, 615, 625, 629; capitalized and underlined), followed by a CFCS (aa 634–637, RSRR; highlighted and underlined) and a TMD (aa 683–703; highlighted).

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